期刊
MINI-REVIEWS IN MEDICINAL CHEMISTRY
卷 15, 期 6, 页码 475-478出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1389557515666150324124751
关键词
Cardiac failure; microRNA; pathological hypertrophy; therapy
资金
- National Natural Science Foundation of China [81200169]
- Innovation Program of Shanghai Municipal Education Commission [13YZ014]
- Foundation for University Young Teachers by Shanghai Municipal Education Commission
- Innovation fund from Shanghai University [sdcx2012038]
- Shanghai Municipal Education Commission
MicroRNAs (miRNAs) are a novel class of endogenous, short, non-coding, posttranscriptional RNAs, which play important roles in regulating lots of important biological functions. Evidences show that altered expression of miRNAs are involved in pathological hypertrophy and cardiac failure, making it possible to target miRNAs as a novel therapy. In this review, we focus on very recent progresses in the regulation of miRNAs in pathological hypertrophy and cardiac failure. In addition, we also discuss the potential of using miRNAs as a new therapy for pathological hypertrophy and cardiac failure.
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