期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 14, 期 8, 页码 17204-17220出版社
MDPI AG
DOI: 10.3390/ijms140817204
关键词
ribonucleoprotein complex; RNA binding protein; microRNAs; drug resistance; mRNA stability; translation
资金
- National Research Foundation of Korea (NRF)
- Korea government (MEST) [2012M3A9D1054476, 2012R1A5A2047939]
- new faculty research fund of Ajou University
Acquisition of drug resistance leads to failure of anti-cancer treatments and therapies. Although several successive chemotherapies are available, along with efforts towards clinical applications of new anti-cancer drugs, it is generally realized that there is a long way to go to treat cancers. Resistance to anti-cancer drugs results from various factors, including genetic as well as epigenetic differences in tumors. Determining the molecular and cellular mechanisms responsible for the acquisition of drug resistance may be a helpful approach for the development of new therapeutic strategies to overcome treatment failure. Several studies have shown that the acquisition of drug resistance is tightly regulated by post-transcriptional regulators such as RNA binding proteins (RBPs) and microRNAs (miRNAs), which change the stability and translation of mRNAs encoding factors involved in cell survival, proliferation, epithelial-mesenchymal transition, and drug metabolism. Here, we review our current understanding of ribonucleoprotein complexes, including RBPs and miRNAs, which play critical roles in the acquisition of drug resistance and have potential clinical implications for cancer.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据