期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 14, 期 5, 页码 9883-9892出版社
MDPI
DOI: 10.3390/ijms14059883
关键词
Rab GTPase; exosome; cancer; extracellular vesicle
资金
- Spearhead Oncology of Ghent University Hospital
- Concerted Research Actions of Ghent University
- Fund for Scientific Research Flanders
The Rab27 family of small GTPases regulates exocytosis of distinct vesicle types including multivesicular endosomes, which results in the release of exosomes. Exosomes are nanometer-sized membrane vesicles that enclose soluble factors such as proteins and nucleic acids within a lipid bilayer and can travel toward distant tissues to influence multiple aspects of cell behavior. In our view that tumors are endocrine organs producing exosomes, Rab27 GTPases and their effector proteins are critical determinants for invasive growth and metastasis. Rab27 proteins and their effectors may serve as prognostic biomarkers or as targets for patient-tailored therapy.
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