期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 13, 期 6, 页码 7776-7787出版社
MDPI AG
DOI: 10.3390/ijms13067776
关键词
hypoxic pulmonary hypertension; remodeling; polydatin; protein kinase C
资金
- National Natural Science Foundation of China [81073107]
- Administration of Traditional Chinese Medicine of Shaanxi Province [zy38]
Hypoxic pulmonary hypertension is a life-threatening emergency if untreated. Consistent pulmonary hypertension also leads to arteries and ventricular remodeling. The clinical therapeutic strategy for pulmonary hypertension and the corresponding remodeling mainly interacts with NO, angiotensin II (Ang II) and elevated endothelin (ET) targets. In the present study, we evaluated the effects of polydatin on hypoxia-induced pulmonary hypertension. It was observed that polydatin attenuated hypoxic pulmonary hypertension, reversed remodeling, and regulated NO, Ang II, ET contents in the serum and lung samples. However, forced activation of PKC signaling by its selective activator thymeleatoxin (THX) could abate the effects of polydatain. These results suggest that polydatin might be a promising candidate for hypoxic pulmonary treatment through interaction with PKC mechanisms.
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