期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 13, 期 8, 页码 10568-10582出版社
MDPI
DOI: 10.3390/ijms130810568
关键词
CA125; MUC16; ovarian cancer; biomarker; mass spectrometry
资金
- Ovarian Cancer Research Foundation
The ovarian cancer biomarker CA125 has been extensively investigated over the last 30 years. The knowledge about the exact molecular nature of this protein, however, remains fragmented. This review provides an overview of the structural research regarding CA125, and presents an orthogonal verification method to confirm the identity of this molecule. The need for independent identification of CA125 is exemplified by several reports where mutually exclusive data concerning the existence of isoforms and the glycan moieties is presented. Mass spectrometry can overcome the pitfalls of a single detection/identification method such as antibody probing. Independent verification of CA125 identity in characterization studies will help establish a refined model of its molecular structure that will promote the development of new approaches for diagnosis, prognosis and therapy of ovarian cancer.
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