期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 13, 期 9, 页码 11071-11084出版社
MDPI
DOI: 10.3390/ijms130911071
关键词
colitis-associated colon cancer; IBD; ulcerative colitis; AOM plus DSS; tumor immunosurveillance; T cells; inflammation; IL-21; IL-6; IL-17
资金
- Fondazione Umberto di Mario ONLUS, Rome
- AIRC [IG-9148, MFAG-12108]
- Giuliani SpA, Milan, Italy
Chronic inflammation characterizing patients with inflammatory bowel disease (IBD) represents a major risk factor for the development of colorectal cancer. Mechanisms underlying this neoplastic transformation are not fully understood though studies in experimental models of colon carcinogenesis suggest that inflammatory cell-derived cytokines either directly or indirectly stimulate the uncontrolled growth of cancer cells. Nevertheless, under specific inflammatory conditions, immune cells can boost an anti-tumor immune response with the down-stream effect of eliminating dysplastic and cancerous cells. This review outlines the beneficial and detrimental role of inflammation in colon carcinogenesis.
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