期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 13, 期 12, 页码 16053-16064出版社
MDPI
DOI: 10.3390/ijms131216053
关键词
miR-218; cervical cancer; HeLa; cisplatin
资金
- Xin Hua Hospital Affiliated, Shanghai Jiao Tong University School of Medicine
MicroRNAs are noncoding RNA molecules of 18-25 nucleotides that regulate gene expression at the post-transcriptional levels. Recent data revealed that miR-218 played key roles in tumor metastasis. Here, we described the regulation and function of miR-218 in cervical cancer. Overexpression of miR-218 reduced the proliferation of the human cervical cancer cell line HeLa and induced cell apoptosis through the AKT-mTOR signaling pathway. In addition, it forced expression of miR-218 suppressed tumor growth in the orthotopic mouse model of HeLa cells. Furthermore, miR-218 increased chemosensitivity to cisplatin (CDDP) in vitro. Our results indicated that targeting miR-218 may provide a strategy for blocking the development of cervical cancer.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据