期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 13, 期 2, 页码 2219-2238出版社
MDPI
DOI: 10.3390/ijms13022219
关键词
inflammation; cholinergic anti-inflammatory pathway; schizophrenia; Alzheimer's disease; cognitive disorder; agonist; antagonist
资金
- Ministry of Education, Youth and Sport of Czech Republic
Alpha7 nicotinic acetylcholine receptor (alpha 7 nAChR) is an important part of the cholinergic nerve system in the brain. Moreover, it is associated with a cholinergic anti-inflammatory pathway in the termination of the parasympathetic nervous system. Antagonists of alpha 7 nAChR are a wide group represented by conotoxin and bungarotoxin. Even Alzheimer's disease drug memantine acting as an antagonist in its side pathway belongs in this group. Agonists of alpha 7 nAChR are suitable for treatment of multiple cognitive dysfunctions such as Alzheimer's disease or schizophrenia. Inflammation or even sepsis can be ameliorated by the agonistic acting compounds. Preparations RG3487, SEN34625/WYE-103914, SEN12333, ABT-107, Clozapine, GTS-21, CNI-1493, and AR-R17779 are representative examples of the novel compounds with affinity toward the alpha 7 nAChR. Pharmacological, toxicological, and medicinal significance of alpha 7 nAChR are discussed throughout this paper.
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