期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 13, 期 12, 页码 15523-15535出版社
MDPI
DOI: 10.3390/ijms131215523
关键词
apoptosis; Bax/Bak translocation; caspase activation cascade; caspase-8/Bid pathway; ginsenoside Rh2
资金
- National Nature Science Foundation of China [30770447, 90813003]
Ginsenoside Rh2 (G-Rh2) has been shown to induce apoptotic cell death in a variety of cancer cells. However, the details of the signal transduction cascade involved in G-Rh2-induced cell death is unclear. In this manuscript we elucidate the molecular mechanism of G-Rh2-induced apoptosis in human hepatoma SK-HEP-1 cells by demonstrating that G-Rh2 causes rapid and dramatic translocation of both Bak and Bax, which subsequently triggers mitochondrial cytochrome c release and consequent caspase activation. Interestingly, siRNA-based gene inactivation of caspase-8 effectively delays caspase-9 activation and apoptosis induced by G-Rh2, indicating that caspase-8 also plays an important role in the G-Rh2-induced apoptosis program. Taken together, our results indicate that G-Rh2 employs a multi pro-apoptotic pathway to execute cancer cell death, suggesting a potential role for G-Rh2 as a powerful chemotherapeutic agent.
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