期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 12, 期 12, 页码 8993-9008出版社
MDPI
DOI: 10.3390/ijms12128993
关键词
Vernonia condensata; antinociceptive activity; sedative effect; anti-inflammatory activity
资金
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
- Fundacao de Amparo a Pesquisa do Estado de Minas Gerais (FAPEMIG)
- Pro-Reitorias de Pesquisa and Pos-Graduacao of the Federal University of Juiz de Fora
The present study was aimed at evaluating the antinociceptive and anti-inflammatory effects of the ethanol extract from Vernonia condensata leaves in animal models, in order to afford a better understanding of these properties. The extract reduced the number of abdominal contortions at doses of 100 (51.00 +/- 3.00), 200 (42.00 +/- 2.98) and 400 mg/kg (39.00 +/- 4.00). In formalin tests, a significant reduction in the licking time (p < 0.01) was observed in the first phase by 25.14 (200 mg/kg = 51.50 +/- 4.44) and 31.15% (400 mg/kg = 48.00 +/- 4.37). The doses of 100 (43.37 +/- 5.15), 200 (34.62 +/- 4.16) and 400 mg/kg (28.37 +/- 3.98) inhibited (p < 0.001) the second phase. After 60 and 90 min of treatment, a dose of 400 mg/kg (10.13 +/- 0.39 and 11.14 +/- 1.33, respectively) increased the latency time. Doses of 200 and 400 mg/kg potentiated the sleeping time induced by diazepam, pentobarbital and meprobamate. The extracts (100, 200 and 400 mg/kg) showed anti-inflammatory effects by a decrease in paw edema. The extracts also reduced the exudate volume at the doses of 200 and 400 mg/kg. The leukocyte migration had significant effect (p < 0.001) at doses of 100, 200 and 400 mg/kg. The completion of additional experiments in the investigation of the antinociceptive and anti-inflammatory activities of V. condensata allowed a better understanding of the central and peripheral mechanisms involved.
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