期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 11, 期 9, 页码 3387-3396出版社
MDPI AG
DOI: 10.3390/ijms11093387
关键词
cyanidin glycosides; intestinal alpha-glucosidase; pancreatic alpha-amylase; synergism
资金
- Government Research Budget, Thailand
- Chulalongkorn University
Cyanidin and its glycosides are naturally dietary pigments which have been indicated as promising candidates to have potential benefits to humans, especially in the prevention and treatment of diabetes mellitus. We investigated the structure activity relationships of cyanidin and its glycosides to inhibit intestinal alpha-glucosidases and pancreatic alpha-amylase in vitro. The results found that cyanidin and its glycosides are more specific inhibitors of intestinal sucrase than intestinal maltase. Cyanidin-3-galactoside and cyanidin-3-glucoside were the most potent inhibitors against intestinal sucrase and pancreatic alpha-amylase with IC50 values of 0.50 +/- 0.05 and 0.30 +/- 0.01 mM, respectively. Our findings indicate that the structural difference between glucose and galactose at the 3-O-position of cyanidin was an important factor for modulating the inhibition of intestinal sucrase and pancreatic alpha-amylase. The combination of cyandin-3-glucoside, cyanidin-3-galactoside or cyanidin-3,5-diglucosides with a low concentration of acarbose showed synergistic inhibition on intestinal maltase and sucrase. The synergistic inhibition was also found for a combination of cyanidin or cyanidin-3-glucoside with a low concentration of acarbose. The findings could provide a new insight into a use for the naturally occurring intestinal alpha-glucosidase and pancreatic alpha-amylase inhibitors for the prevention and treatment of diabetes and its complications.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据