期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 11, 期 4, 页码 1413-1422出版社
MDPI
DOI: 10.3390/ijms11041413
关键词
peptide; near-infrared fluorescence; quantum dots; tumor; growth; proliferation; apoptosis; metastasis
资金
- National Natural Science Foundation of China [30872925]
Quantum dots (QDs) have great potential in non-invasive monitoring and imaging of tumor cells in vivo, but it is unknown if QDs affect their tumorigenesis and metastasis. Here, we applied peptide-conjugated near-infrared fluorescent QDs (NIRF-QDs) to label the squamous cell carcinoma cells Tca8113 and U14. We tested the proliferation and apoptotic capacities of both cells, and the capacity of cervical lymph node metastasis after tumorigenesis in U14 cells'. We find that QDs do not affect the tumor cells' capacities to grow, proliferate, and metastasize. Our study provides critical data to support the application of NIRF-QDs in non-invasive monitoring and imaging of tumor cells in vivo.
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