相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。The PINK1-Parkin pathway is involved in the regulation of mitochondrial remodeling process
Jeehye Park et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2009)
Regulation of Neuronal Survival Factor MEF2D by Chaperone-Mediated Autophagy
Qian Yang et al.
SCIENCE (2009)
Ubiquitination of alpha-synuclein and autophagy in Parkinson's disease
Simone Engelender
AUTOPHAGY (2008)
PINK1 controls mitochondrial localization of Parkin through direct phosphorylation
Yongsung Kim et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2008)
alpha-Synuclein Misfolding and Neurodegenerative Diseases
Vladimir N. Uversky
CURRENT PROTEIN & PEPTIDE SCIENCE (2008)
Rhomboid-7 and HtrA2/Omi act in a common pathway with the Parkinson's disease factors Pink1 and Parkin
Alexander J. Whitworth et al.
DISEASE MODELS & MECHANISMS (2008)
Cell systems and the toxic mechanism(s) of alpha-synuclein
Mark R. Cookson et al.
EXPERIMENTAL NEUROLOGY (2008)
The S18Y polymorphic variant of UCH-L1 confers an antioxidant function to neuronal cells
Elli Kyratzi et al.
HUMAN MOLECULAR GENETICS (2008)
Parkin mitochondria in the autophagosome
Heidi M. McBride
JOURNAL OF CELL BIOLOGY (2008)
Parkin is recruited selectively to impaired mitochondria and promotes their autophagy
Derek Narendra et al.
JOURNAL OF CELL BIOLOGY (2008)
Assessment of α-synuclein pathology:: A study of the BrainNet Europe consortium
Irina Alafuzoff et al.
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2008)
Mitochondria in the aetiology and pathogenesis of Parkinson's disease
Anthony H. V. Schapira
LANCET NEUROLOGY (2008)
Protein aggregation in the brain: The molecular basis for Alzheimer's and Parkinson's diseases
G. Brent Irvine et al.
MOLECULAR MEDICINE (2008)
Differential expression of alpha-synuclein, parkin, and synphilin-1 isoforms in Lewy body disease
Katrin Beyer et al.
NEUROGENETICS (2008)
The PINK1/Parkin pathway regulates mitochondrial morphology
Angela C. Poole et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Lysosomal enzyme cathepsin D protects against alpha-synuclein aggregation and toxicity
Liyan Qiao et al.
Molecular Brain (2008)
Ubiquitination of α-synuclein by Siah-1 promotes α-synuclein aggregation and apoptotic cell death
James T. Lee et al.
HUMAN MOLECULAR GENETICS (2008)
Monoubiquitylation of α-synuclein by seven in absentia homolog (SIAH) promotes its aggregation in dopaminergic cells
Ruth Rott et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Identification and characterization of a new alpha-synuclein isoform and its role in Lewy body diseases
Katrin Beyer et al.
NEUROGENETICS (2008)
Synphilin-1 isoforms in Parkinson's disease: regulation by phosphorylation and ubiquitylation
R. Szargel et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2008)
Protein aggregation mechanisms in synucleinopathies: Commonalities and differences
Katrin Beyer et al.
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2007)
The mitochondrial protease HtrA2 is regulated by Parkinson's disease-associated kinase PINK1
Helene Plun-Favreau et al.
NATURE CELL BIOLOGY (2007)
The Lewy body in Parkinson's disease:: Molecules implicated in the formation and degradation of α-synuclein aggregates
Koichi Wakabayashi et al.
NEUROPATHOLOGY (2007)
In dementia with Lewy bodies, Braak stage determines phenotype, not Lewy body distribution
D. Weisman et al.
NEUROLOGY (2007)
The functions of UCH-L1 and its relation to neurodegenerative diseases
Rieko Setsuie et al.
NEUROCHEMISTRY INTERNATIONAL (2007)
The proteasomal subunit S6 ATPase is a novel synphilin-1 interacting protein -: implications for Parkinson's disease
Frank P. Marx et al.
FASEB JOURNAL (2007)
Parkin and synphilin-1 isoform expression changes in Lewy body diseases
Jordi Humbert et al.
NEUROBIOLOGY OF DISEASE (2007)
Pink1, Parkin, DJ-1 and mitochondrial dysfunction in Parkinson's disease
Mark W. Dodson et al.
CURRENT OPINION IN NEUROBIOLOGY (2007)
A variable poly-T sequence modulates α-synuclein isoform expression and is associated with aging
Katrin Beyer et al.
JOURNAL OF NEUROSCIENCE RESEARCH (2007)
Phosphorylation of parkin by the cyclin-dependent kinase 5 at the linker region modulates its ubiquitin-ligase activity and aggregation
Eyal Avraham et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Aggregated α-synuclein mediates dopaminergic neurotoxicity in vivo
Magali Periquet et al.
JOURNAL OF NEUROSCIENCE (2007)
Mitochondrial dysfunction, peroxidation damage and changes in glutathione metabolism in PARK6
Hans-Hermann Hoepken et al.
NEUROBIOLOGY OF DISEASE (2007)
S18Y in ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) associated with decreased risk of Parkinson's disease in Sweden
Andrea Carmine Belin et al.
PARKINSONISM & RELATED DISORDERS (2007)
Understanding the molecular causes of Parkinson's disease
A. Wood-Kaczmar et al.
TRENDS IN MOLECULAR MEDICINE (2006)
α-synuclein acts in the nucleus to inhibit histone acetylation and promote neurotoxicity
Eirene Kontopoulos et al.
HUMAN MOLECULAR GENETICS (2006)
Phosphorylation of Ser-129 is the dominant pathological modification of α-synuclein in familial and sporadic Lewy body disease
John P. Anderson et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Synphilin isoforms and the search for a cellular model of Lewy body formation in Parkinson's disease
Allon Eyal et al.
CELL CYCLE (2006)
Low alpha-synuclein 126 mRNA levels in dementia with Lewy bodies and Alzheimer disease
Katrin Beyer et al.
NEUROREPORT (2006)
Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused inactivation of Drosophila Pink1 is rescued by by Parkin
Yufeng Yang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Altered cleavage and localization of PINK1 to aggresomes in the presence of proteasomal stress
Miratul M. K. Muqit et al.
JOURNAL OF NEUROCHEMISTRY (2006)
PINK1 protein in normal human brain and Parkinson's disease
S. Gandhi et al.
BRAIN (2006)
Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin
Ira E. Clark et al.
NATURE (2006)
Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin
Jeehye Park et al.
NATURE (2006)
Synphilin-1A:: An aggregation-prone isoform of synphilin-1 that causes neuronal death and is present in aggregates from α-synucleinopathy patients
A Eyal et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Lewy bodies
CW Shults
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Clinical heterogeneity of α-synuclein gene duplication in Parkinson's disease
K Nishioka et al.
ANNALS OF NEUROLOGY (2006)
Parkinson's disease: the genetics of a heterogeneous disorder
D. Gosal et al.
EUROPEAN JOURNAL OF NEUROLOGY (2006)
Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): Report of the Consortium on DLB International Workshop
Ian G. McKeith
JOURNAL OF ALZHEIMERS DISEASE (2006)
alpha-Synuclein structure, posttranslational modification and alternative splicing as aggregation enhancers
Katrin Beyer
ACTA NEUROPATHOLOGICA (2006)
Glycogen synthase kinase 3β modulates synphilin-1 ubiquitylation and cellular inclusion formation by SIAH -: Implications for proteasomal function and Lewy body formation
E Avraham et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Diagnosis and management of dementia with Lewy bodies - Third report of the DLB consortium
IG McKeith et al.
NEUROLOGY (2005)
The dardarin G2019S mutation is a common cause of Parkinson's disease but not other neurodegenerative diseases
D Hernandez et al.
NEUROSCIENCE LETTERS (2005)
Widespread and abundant α-synuclein pathology in a neurologically unimpaired subject
L Parkkinen et al.
NEUROPATHOLOGY (2005)
Mitochondrial import and enzymatic activity of PINK1 mutants associated to recessive parkinsonism
L Silvestri et al.
HUMAN MOLECULAR GENETICS (2005)
Loss of function mutations in the gene encoding Omi/HtrA2 in Parkinson's disease
KM Strauss et al.
HUMAN MOLECULAR GENETICS (2005)
Small-molecule inhibition of proteasome and aggresome function induces synergistic antitumor activity in multiple myeloma
T Hideshima et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Parkin mediates nonclassical, proteasomal-independent ubiquitination of synphilin-1: Implications for Lewy body formation
KL Lim et al.
JOURNAL OF NEUROSCIENCE (2005)
Glycogen synthase kinase 3β (GSK3β) mediates 6-hydroxydopamine-induced neuronal death
G Chen et al.
FASEB JOURNAL (2004)
Mitochondrial dysfunction and oxidative damage in parkin-deficient mice
JJ Palacino et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Ubiquitylation of synphilin-1 and α-synuclein by SIAH and its presence in cellular inclusions and Lewy bodies imply a role in Parkinson's disease
E Liani et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
UCHL1 is a Parkinson's disease susceptibility gene
DM Maraganore et al.
ANNALS OF NEUROLOGY (2004)
Tau isoforms which contain the domain encoded by exon 6 and their role in neurite elongation
MH Luo et al.
JOURNAL OF CELLULAR BIOCHEMISTRY (2004)
Casein kinase II-mediated phosphorylation regulates α-synuclein/synphilin-1 interaction and inclusion body formation
G Lee et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Aggresomes formed by α-synuclein and synphilin-1 are cytoprotective
M Tanaka et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
The new mutation, E46K, of α-synuclein causes Parkinson and Lewy body dementia
JJ Zarranz et al.
ANNALS OF NEUROLOGY (2004)
Mitochondrial protease Omi/HtrA2 enhances caspase activation through multiple pathways
Y Suzuki et al.
CELL DEATH AND DIFFERENTIATION (2004)
Distribution, type, and origin of Parkin mutations:: Review and case studies
K Hedrich et al.
MOVEMENT DISORDERS (2004)
β-Synuclein gene alterations in dementia with Lewy bodies
H Ohtake et al.
NEUROLOGY (2004)
Parkin transcript variants in rat and human brain
V D'Agata et al.
NEUROCHEMICAL RESEARCH (2004)
Expression of truncated presenilin 2 splice variant in Alzheimer's disease, bipolar disorder, and schizophrenia brain cortex
MJ Smith et al.
MOLECULAR BRAIN RESEARCH (2004)
Pathogenetic mechanisms of parkin in Parkinson's disease
N Hattori et al.
LANCET (2004)
A limited role for DJ1 in Parkinson disease susceptibility
DM Maraganore et al.
NEUROLOGY (2004)
Autophagy: Many paths to the same end
AM Cuervo
MOLECULAR AND CELLULAR BIOCHEMISTRY (2004)
Differential expression of α-synuclein isoforms in dementia with Lewy bodies
K Beyer et al.
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY (2004)
Alternative splicing in the N-terminus of Alzheimer's presenilin 1
W Scheper et al.
NEUROGENETICS (2004)
TPPP/p25:: from unfolded protein to misfolding disease:: prediction and experiments
F Orosz et al.
BIOLOGY OF THE CELL (2004)
Novel isoforms of tau that lack the microtubule-binding domain
MH Luo et al.
JOURNAL OF NEUROCHEMISTRY (2004)
Structure of membrane-bound α-synuclein studied by site-directed spin labeling
CC Jao et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
S-nitrosylation of Parkin regulates ubiquitination and compromises Parkin's protective function
KKK Chung et al.
SCIENCE (2004)
Drosophila parkin mutants have decreased mass and cell size and increased sensitivity to oxygen radical stress
Y Pesah et al.
DEVELOPMENT (2004)
Mitochondrial complex I and IV activities in leukocytes from patients with parkin mutations
M Müftüoglu et al.
MOVEMENT DISORDERS (2004)
Siah-1 facilitates ubiquitination and degradation of synphilin-1
Y Nagano et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Cyclin-dependent kinase 5 is a mediator of dopaminergic neuron loss in a mouse model of Parkinson's disease
PD Smith et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Ubiquitination of α-synuclein in Lewy bodies is a pathological event not associated with impairment of proteasome function
GK Tofaris et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
α-synuclein locus triplication causes Parkinson's disease
AB Singleton et al.
SCIENCE (2003)
A protein-chameleon:: Conformational plasticity of α-synuclein, a disordered protein involved in neurodegenerative disorders
VN Uversky
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS (2003)
Nuclear localization of α-synuclein and its interaction with histones
J Goers et al.
BIOCHEMISTRY (2003)
Developmental stages of cortical Lewy bodies and their relation to axonal transport blockage in brains of patients with dementia with Lewy bodies
O Katsuse et al.
JOURNAL OF THE NEUROLOGICAL SCIENCES (2003)
α-synuclein is degraded by both autophagy and the proteasome
JL Webb et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Identification and functional characterization of a novel R621C mutation in the synphilin-1 gene in Parkinson's disease
FP Marx et al.
HUMAN MOLECULAR GENETICS (2003)
Influence of Alzheimer pathology on clinical diagnostic accuracy in dementia with Lewy bodies
AR Merdes et al.
NEUROLOGY (2003)
Idiopathic Parkinson's disease:: possible routes by which vulnerable neuronal types may be subject to neuroinvasion by an unknown pathogen
H Braak et al.
JOURNAL OF NEURAL TRANSMISSION (2003)
Alterations of structure and hydrolase activity of Parkinsonism-associated human ubiquitin carboxyl-terminal hydrolase L1 variants
K Nishikawa et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2003)
Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutants
JC Greene et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Neuropathological spectrum of synucleinopathies
KA Jellinger
MOVEMENT DISORDERS (2003)
Morphogenesis of Lewy bodies: Dissimilar incorporation of alpha-synuclein, ubiquitin, and p62
E Kuusisto et al.
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2003)
Phosphorylated α-synuclein is ubiquitinated in α-synucleinopathy lesions
M Hasegawa et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Parkin accumulation in aggresomes due to proteasome impairment
E Junn et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
The UCH-L1 gene encodes two opposing enzymatic activities that affect α-synuclein degradation and Parkinson's disease susceptibility
YC Liu et al.
CELL (2002)
α-synuclein, especially the Parkinson's disease-associated mutants, forms pore-like annular and tubular protofibrils
HA Lashuel et al.
JOURNAL OF MOLECULAR BIOLOGY (2002)
Heterogeneity of nigral and cortical Lewy bodies differentiated by amplified triple-labeling for alpha-synuclein, ubiquitin, and thiazin red
M Sakamoto et al.
EXPERIMENTAL NEUROLOGY (2002)
Analysis of synphilin-1 and synuclein interactions by yeast two-hybrid β-galactosidase liquid assay
M Neystat et al.
NEUROSCIENCE LETTERS (2002)
Regulation of synaptophysin degradation by mammalian homologues of Seven in Absentia
TC Wheeler et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Identification of Omi/HtrA-2 as a mitochondrial apoptotic serine protease that disrupts inhibitor of apoptosis protein-caspase interaction
R Hegde et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Membrane-bound α-synuclein has a high aggregation propensity and the ability to seed the aggregation of the cytosolic form
HJ Lee et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Research evaluation and prospective diagnosis of dementia with Lewy bodies
OL Lopez et al.
ARCHIVES OF NEUROLOGY (2002)
The solubility of alpha-synuclein in multiple system atrophy differs from that of dementia with Lewy bodies and Parkinson's disease
BCV Campbell et al.
JOURNAL OF NEUROCHEMISTRY (2001)
Parkin ubiquitinates the α-synuclein-interacting protein, synphilin-1:: implications for Lewy-body formation in Parkinson disease
KKK Chung et al.
NATURE MEDICINE (2001)
A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death
Y Suzuki et al.
MOLECULAR CELL (2001)
Ubiquitination of a new form of α-synuclein by parkin from human brain:: Implications for Parkinson's disease
H Shimura et al.
SCIENCE (2001)
Identification of the region of non-Aβ component (NAC) of Alzheimer's disease amyloid responsible for its aggregation and toxicity
AM Bodles et al.
JOURNAL OF NEUROCHEMISTRY (2001)
Clinical and pathologic abnormalities in a family with parkinsonism and parkin gene mutations
BPC van de Warrenburg et al.
NEUROLOGY (2001)
A hydrophobic stretch of 12 amino acid residues in the middle of α-synuclein is essential for filament assembly
BI Giasson et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Proteasomal function is impaired in substantia nigra in Parkinson's disease
KSP McNaught et al.
NEUROSCIENCE LETTERS (2001)
Toxicity of non-Aβ component of Alzheimer's disease amyloid, and N-terminal fragments thereof, correlates to formation of β-sheet structure and fibrils
AM Bodles et al.
EUROPEAN JOURNAL OF BIOCHEMISTRY (2000)
α-Synuclein immunoreactivity in dementia with Lewy bodies:: morphological staging and comparison with ubiquitin immunostaining
E Gómez-Tortosa et al.
ACTA NEUROPATHOLOGICA (2000)
Complex regulation of tau exon 10, whose missplicing causes frontotemporal dementia
QS Gao et al.
JOURNAL OF NEUROCHEMISTRY (2000)
分享论文
