期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 10, 期 10, 页码 4375-4417出版社
MDPI
DOI: 10.3390/ijms10104375
关键词
vascular graft; extracellular matrix; healing; native regenerative processes
资金
- Enterprise Ireland Technical Development Fund [CFTD 2007/131]
- Irish Research Council for Science, Engineering and Technology (IRCSET)
The in vivo healing process of vascular grafts involves the interaction of many contributing factors. The ability of vascular grafts to provide an environment which allows successful accomplishment of this process is extremely difficult. Poor endothelisation, inflammation, infection, occlusion, thrombosis, hyperplasia and pseudoaneurysms are common issues with synthetic grafts in vivo. Advanced materials composed of decellularised extracellular matrices (ECM) have been shown to promote the healing process via modulation of the host immune response, resistance to bacterial infections, allowing re-innervation and reestablishing homeostasis in the healing region. The physiological balance within the newly developed vascular tissue is maintained via the recreation of correct biorheology and mechanotransduction factors including host immune response, infection control, homing and the attraction of progenitor cells and infiltration by host tissue. Here, we review the progress in this tissue engineering approach, the enhancement potential of ECM materials and future prospects to reach the clinical environment.
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