期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 10, 期 7, 页码 2935-2957出版社
MDPI
DOI: 10.3390/ijms10072935
关键词
G-quadruplex; isothermal titration calorimetry; thermodynamic; drug
资金
- Italian Ministero dell'Universita e della Ricerca [2007EBYL8L_005]
- COST Action [MP0802]
G-quadruplexes are higher-order nucleic acids structures formed by G-rich sequences that are stabilized by tetrads of hydrogen-bonded guanine bases. Recently, there has been growing interest in the study of G-quadruplexes because of their possible involvement in many biological processes. Isothermal titration calorimetry (ITC) has been proven to be a useful tool to study the energetic aspects of G-quadruplex interactions. Particularly, ITC has been applied many times to determine the thermodynamic properties of drug-quadruplex interactions to screening among various drugs and to address drug design. In the present review, we will focus on the ITC studies of G-quadruplex structures and their interaction with proteins and drugs and the most significant results will be discussed.
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