期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 10, 期 3, 页码 1161-1192出版社
MDPI
DOI: 10.3390/ijms10031161
关键词
Systems Biology; Molecular Systems Bioenergetics; cellular energy metabolism; regulation; compartmentation; energy transfer systems
资金
- INSERM, France
- Agence Nationale de la Recherche [ANR07-BLAN-0086-01]
- Estonian Science Foundation [Ndegrees7117, 6142]
We live in times of paradigmatic changes for the biological sciences. Reductionism, that for the last six decades has been the philosophical basis of biochemistry and molecular biology, is being displaced by Systems Biology, which favors the study of integrated systems. Historically, Systems Biology - defined as the higher level analysis of complex biological systems - was pioneered by Claude Bernard in physiology, Norbert Wiener with the development of cybernetics, and Erwin Schrodinger in his thermodynamic approach to the living. Systems Biology applies methods inspired by cybernetics, network analysis, and non-equilibrium dynamics of open systems. These developments follow very precisely the dialectical principles of development from thesis to antithesis to synthesis discovered by Hegel. Systems Biology opens new perspectives for studies of the integrated processes of energy metabolism in different cells. These integrated systems acquire new, system-level properties due to interaction of cellular components, such as metabolic compartmentation, channeling and functional coupling mechanisms, which are central for regulation of the energy fluxes. State of the art of these studies in the new area of Molecular System Bioenergetics is analyzed.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据