期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 9, 期 1, 页码 56-64出版社
MDPI AG
DOI: 10.3390/ijms9010056
关键词
dietary flavonoids; TRAIL; HeLa; chemoprevention; antitumoral activity
TRAIL is a promising candidate for cancer therapeutics that preferentially induces apoptosis in cancer cells. The combined treatment flavonoids with TRAIL might be promising as a chemoprevention and/or new therapy against malignant tumors. We examined the cytotoxic effect of dietary flavonoids in combination with TRAIL on HeLa cells. It was found that treatment with noncytotoxic concentration of some flavonoids significantly sensititizes to TRAIL induced death in HeLa cells. Our study demonstrated that flavone, apigenin and genistein markedly augmented TRAIL mediated cytotoxicity against HeLa, whereas kaempferol and quercetin produced no effect.
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