期刊
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
卷 32, 期 5, 页码 1021-1028出版社
SPANDIDOS PUBL LTD
DOI: 10.3892/ijmm.2013.1486
关键词
aging; myelin proteins; astrocyte; microglia; central nervous system; mapping
资金
- Major State Basic Research Development Program of China (973 Program) [2011CB504100, 2013BAI04B04]
- National Natural Science Foundation of China [81171049]
It has been shown that aging can greatly influence the integrity and ultrastructure of white matter and the myelin sheath; however, studies regarding the effects of aging on the expression of myelin proteins are still limited. In the present study, immunohistochemical mapping was used to investigate the overall expression of myelin basic protein (Mbp) and myelin oligodendrocyte glycoprotein (Mog) in the central nervous system (CNS) of rats in postnatal months 2, 5, 18 and 26. Astrocyte and microglia activation was also detected by glial fibrillary acidic protein (GFAP) or ionized calcium-binding adaptor molecule 1 (Iba1) staining and western blotting. A significant decline of Mbp and Mog was identified as a universal alteration in the CNS of aged rats. Aging also induced significant astrocyte and microglial activation. Correlation analysis indicated a negative correlation between the reduction of age-related myelin proteins and glial activation in aging. This correlation of myelin breakdown and glial activation in aging may reveal new evidence in connecting the inflammation and myelin breakdown mechanism of age-related neurodegenerative diseases.
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