期刊
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
卷 30, 期 6, 页码 1410-1416出版社
SPANDIDOS PUBL LTD
DOI: 10.3892/ijmm.2012.1147
关键词
grape seed proanthocyanidin; colon cancer; angiogenesis; vascular endothelial growth factor; angiopoietin 1; reactive oxygen species
资金
- National Natural Science Foundation of China [30700142]
- Scientific Research Innovation Team of Northwest University for Nationalities [BMUCXTD-2011-1]
Tumor cells trigger angiogenesis through overexpression of various angiogenic factors including vascular endothelial growth factor (VEGF) and angiopoietin 1 (Ang1). Therefore, inhibition of the expression of both VEGF and Ang1, the initial step of tumor angiogenesis, is a promising strategy for cancer chemoprevention and therapy. Grape seed proanthocyanidins (GSPs) are widely consumed dietary supplements that have antitumor activity. Due to their polymeric structure, GSPs are poorly absorbed along the gastrointestinal tract and can reach the colon at high concentrations, allowing these chemicals to act as chemopreventive agents for colon cancer. In the present study, we found that GSPs inhibited colon tumor-induced angiogenesis and, thus, the growth of colon tumor xenografts on the chick chorioallantoic membranes. The mechanisms of their action were related to inhibiting the expression of both VEGF and Ang1 through scavenging reactive oxygen species. Previous studies have demonstrated that the chemopreventive effects of GSPs on colon cancer are associated with their growth inhibitory and apoptosis-inducing effects. Our results demonstrate another mechanism by which GSPs inhibit colon tumor growth, which will be helpful for developing GSPs as a pharmacologically safe angiopreventive agent against colorectal cancer.
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