期刊
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
卷 11, 期 9, 页码 925-935出版社
IVYSPRING INT PUBL
DOI: 10.7150/ijms.8951
关键词
serum alanine aminotransferase; ALT; activity
资金
- National Nature Science Foundation of China [NSFC 81072321, 30760243, 30460143, 30560133]
- Program for New Century Excellent Talents in University (NCET)
- Guangxi Nature Sciences Grant [GuiKeGong 1104003A-7]
- Guangxi Health Ministry Medicine Grant (Key-Scientific-Research-Grant) [Z201018]
- Programs for Changjiang Scholars and Innovative Research Team in University [IRT1119]
- Innovative Research Team in Guangxi Natural Science Foundation [2011GXNSFF018005]
Measurement of serum alanine aminotransferase (ALT) is a common, readily available, and inexpensive laboratory assay in clinical practice. ALT activity is not only measured to detect liver disease, but also to monitor overall health. ALT activity is influenced by various factors, including viral hepatitis, alcohol consumption, and medication. Recently, the impact of metabolic abnormalities on ALT variation has raised concern due to the worldwide obesity epidemic. The normal ranges for ALT have been updated and validated considering the metabolic covariates in the various ethnic districts. The interaction between metabolic and demographic factors on ALT variation has also been discussed in previous studies. In addition, an extremely low ALT value might reflect the process of aging, and frailty in older adults has been raised as another clinically significant feature of this enzyme, to be followed with additional epidemiologic investigation. Timely updated, comprehensive, and systematic introduction of ALT activity is necessary to aid clinicians make better use of this enzyme.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据