期刊
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
卷 10, 期 11, 页码 1575-1577出版社
IVYSPRING INT PUBL
DOI: 10.7150/ijms.6436
关键词
HCV; ribavirin; anemia; metabolome; glycolysis; pentose phosphate cycle
资金
- Japan Science and Technology Agency
- Ministry of Health, Labor and Welfare of Japan
- Grants-in-Aid for Scientific Research [22134007, 23592784] Funding Source: KAKEN
Ribavirin is one of the major agents used in combination therapy with interferon for chronic hepatitis C, but is often associated with hemolytic anemia as a serious adverse event. Employing metabolome analysis, we demonstrated that the concentrations of intermediate metabolites produced by glycolysis and the pentose phosphate cycle in patients' erythrocytes were significantly decreased after administration of ribavirin. Our findings suggest that hemolysis associated with ribavirin is triggered by an energy crisis and consequent oxidative stress, thus having implications for the prevention of such hemolysis.
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