期刊
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
卷 10, 期 11, 页码 1430-1436出版社
IVYSPRING INT PUBL
DOI: 10.7150/ijms.6645
关键词
arterial stiffness; cardiovascular disease; chronic kidney disease; pulse wave velocity
资金
- National Research Foundation of Korea (NRF)
- Ministry of Education, Science, and Technology, Republic of Korea [20110013312]
Objective: In this study, we investigated the predictive capacity of the brachial-ankle aortic pulse wave velocity (baPWV), a marker of arterial stiffness, for the decline in renal function and for cardiovascular events in the early stages of chronic kidney disease (CKD). Method: Two hundred forty-one patients who underwent a comprehensive check-up were included and were divided into two groups according to their estimated glomerular filtration rates (eGFR): patients with CKD categories G2, G3a and G3b (30 <= eGFR < 90 ml/min/1.73m(2), eGFR < 90 group; n=117) and those with eGFR >= 90 ml/min/1.73 m(2) (eGFR >= 90 group; n=124). The change in renal function, the eGFR change, was determined by the slope of eGFR against time. We analysed whether baPWV was associated with eGFR change or predicted cardiovascular events. Results: baPWV was independently associated with eGFR change in a multivariate analysis of the total patients (beta=-0.011, p=0.011) and remained significantly associated with eGFR change in a subgroup analysis of the eGFR < 90 group (beta=-0.015, p=0.035). baPWV was independently associated with cardiovascular events (odds ratio=1.002, p=0.048) in the eGFR < 90 group, but not in the eGFR >= 90 group. The receiver operative characteristic curve analysis showed that 1,568 cm/sec was the cut-off value of baPWV for predicting CV events in the eGFR < 90 group (area under curve=0.691, p=0.03) Conclusions: In patients with early stages of CKD, baPWV was independently associated with the decline in renal function and short-term cardiovascular events.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据