期刊
INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY
卷 304, 期 2, 页码 110-120出版社
ELSEVIER GMBH
DOI: 10.1016/j.ijmm.2013.11.007
关键词
Physiological proteomics; Entire proteome; 2D gel electrophoresis; MS-based proteomics; Stress/starvation responses; Virulence factors; Surfacome; Membrane vesicles; Biofilms
资金
- European Commission-funded project [LSHG-CT-2006-037469]
Staphylococcus aureus is a Gram-positive commensal bacterium that is regarded as a major threat for modern health care systems. This relates both to the ability of S. aureus to overcome antibiotic therapy by developing high-level resistance against multiple antibiotics and this bacterium's extensive arsenal of virulence factors. Understanding the mechanisms of resistance and functional studies on stress and starvation responses are the-main goals of proteomics in staphylococcal research. This review high-lights recent advances in gel-based and gel-free proteomics analyses of S. aureus and pinpoints the importance of location-specific proteomics studies targeting the cytosol, the membrane, the cell surface and the extracellular milieu in combination with integrated global proteome studies. Emerging hot topics in staphylococcal proteomics are discussed with special focus on in vivo proteomics, membrane vesicles, biofilm formation and the acquisition of absolute proteome data for systems biological modeling approaches. (c) 2013 Elsevier GmbH. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据