期刊
INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY
卷 300, 期 2-3, 页码 176-192出版社
ELSEVIER GMBH, URBAN & FISCHER VERLAG
DOI: 10.1016/j.ijmm.2009.10.002
关键词
Staphylococcus aureus; Immune proteome; Adaptive immune system; Antibodies; Vaccine
资金
- Deutsche Forschungsgemeinschaft [SFB-TR34, GRK-840]
This review provides an overview of the antibody response against Staphylococcus aureus, which challenges the adaptive immune system with a broad and highly variable antigen repertoire. The mechanisms by which antibodies shape the interaction between S. aureus and its host are introduced, and evidence for a role of adaptive immunity in the protection against S. aureus is discussed. Techniques are now available to map the core and the variable S. aureus immune proteomes, which constitute the knowledge base for the design of effective anti-S. aureus vaccine compositions. This will require coordinated approaches that match the antigen repertoire of an infecting or colonizing S. aureus strain with the individual antibody response directed against it. (C) 2009 Elsevier GmbH. All rights reserved.
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