期刊
INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY
卷 298, 期 -, 页码 257-267出版社
ELSEVIER GMBH
DOI: 10.1016/j.ijmm.2007.09.004
关键词
Borrelia burgdorferi; outer surface protein; adhesin; complement; factor H; laminin
资金
- NIAID NIH HHS [R01-AI44245, R01 AI044254-08, R01 AI044254] Funding Source: Medline
Lyme borreliae naturally maintain numerous distinct DNA elements of the cp32 family, each of which carries a mono- or bicistronic erp locus. The encoded Erp proteins are surface-exposed outer membrane lipoproteins that are produced at high levels during mammalian infection but largely repressed during colonization of vector ticks. Recent studies have revealed that some Erp proteins can serve as bacterial adhesins, binding host proteins such as the complement regulator factor H and the extracellular matrix component laminin. These results suggest that Erp proteins play roles in multiple aspects of mammalian infection. (C) 2008 Elsevier GmbH. All rights reserved.
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