期刊
INTERNATIONAL JOURNAL OF MASS SPECTROMETRY
卷 298, 期 1-3, 页码 45-54出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijms.2010.01.006
关键词
Differential mobility spectrometry; Ion mobility; Atmospheric pressure ion pre-filtering; Mass spectrometry; Modeling
资金
- NIH (NIAID) [U19 AI067773-04]
Ion filters based on planar DMS can be integrated with the inlet configuration of most mass spectrometers, and are able to enhance the quality of mass analysis and quantitative accuracy by reducing chemical noise, and by pre-separating ions of similar mass. This paper is the first in a series of papers describing the optimization of DMS/MS instrumentation. In this paper the important physical parameters of a planar DMS-MS interface including analyzer geometry, analyzer coupling to a mass spectrometer, and transport gas flow control are considered. The goal is to optimize ion transmission and transport efficiency, provide optimal and adjustable resolution, and produce stable operation under conditions of high sample contamination. We discuss the principles of DMS separations and highlight the theoretical underpinnings. The main differences between planar and cylindrical geometries are presented, including a discussion of the advantages and disadvantages of RF ion focusing. In addition, we present a description of optimization of the frequency and amplitude of the DMS fields for resolution and ion transmission, and a discussion of the influence and importance of ion residence time in DMS. We have constructed a mass spectrometer interface for planar geometries that takes advantage of atmospheric pressure gas dynamic principles, rather than ion focusing, to minimize ion losses from diffusion in the analyzer and to maximize total ion transport into the mass spectrometer. A variety of experimental results has been obtained that illustrate the performance of this type of interface, including tests of resistance to high contamination levels, and the separation of stereoisomers. In a subsequent publication the control of the chemical interactions that drive the separation process of a DMS/MS system will be considered. In a third publication we describe novel electronics designed to provide the high voltage asymmetric waveform fields (SV) required for these devices as well as the effects of different waveforms. (C) 2010 Elsevier B.V. All rights reserved.
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