期刊
INTERNATIONAL JOURNAL OF MASS SPECTROMETRY
卷 290, 期 2-3, 页码 94-99出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijms.2009.12.008
关键词
Chitosan oligosaccharide; Polymerization degree; Acetyl group; Matrix-assisted laser desorption/ionization; time-of-flight mass spectrometry; Structure-activity relationship
COS have many biological activities, and have been widely used as a health food. Molecular size is considered as a key parameter for COS' activities. However, many criteria are used practically, and true qualities of COS from different producers may not be always comparable. This can partly explain the disagreement in COS' functional researches. as resulting in COS. even with astonish effects, have not been further developed as a drug for tumor patients. As anti-tumor activities have been studied based on DP in pharmacological researches, we employed MALDI-TOF-MS to monitor fine structure, including DP, in COS' preparation and comparison. Then one or the COS products was analyzed with the composition of DP 5-12, mainly 7-10. Moreover, that COS' product contains well-distributed acetyl groups, while typical Commercial COS sample nearly contains no acetyl groups. As fresh precise parameters, the DP and the number of acetyl groups matching with special DP can be introduced in COS' further study on structure-activity relationships (SARs) as a new drug. (C) 2009 Elsevier B.V. All rights reserved.
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