期刊
INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY
卷 34, 期 1, 页码 14-20出版社
WILEY
DOI: 10.1111/j.1751-553X.2011.01367.x
关键词
Haemoglobin F; high-performance liquid chromatography; capillary electrophoresis; recommended methods; haemoglobinopathy; thalassaemia
类别
Measurement of the Haemoglobin F in red cell haemolysates is important in the diagnosis of d beta thalassaemia, hereditary persistence of fetal haemoglobin (HPFH) and in the diagnosis and management of sickle cell disease. The distribution of Hb F in red cells is useful in the diagnosis of HPFH and in the assessment of feto-maternal haemorrhage. The methods of quantifying Hb F are described together with pitfalls in undertaking these laboratory tests with particular emphasis on automated high-performance liquid chromatography and capillary electrophoresis.
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