期刊
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
卷 14, 期 11, 页码 E1013-E1017出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.ijid.2010.06.016
关键词
Nevirapine; Rifampin; HIV; Tuberculosis; Thailand
资金
- Department of Disease Control, Ministry of Public Health, Thailand
Background: The concurrent use of nevirapine-based antiretroviral therapy (ART) and rifampin-containing anti-tuberculosis regimens for the treatment of HIV and tuberculosis (TB) is common in resource-limited countries. Long-term outcomes of this concurrent treatment are unknown. Methods: Seventy HIV-infected patients receiving rifampin for active TB (TB group) and 70 HIV-monoinfected patients (control group) were enrolled to receive nevirapine 400 mg/day-based ART. All were followed through 4 years of ART. Plasma HIV-1 RNA and CD4 cell counts were monitored every 12 weeks until 96 weeks, and every 24 weeks thereafter. Results: Of the 140 patients, the median (interquartile range (IQR)) CD4 count was 31 (14-79) cells/mm(3) and median (IQR) plasma HIV-1 RNA was 5.6 (5.2-5.9) log copies/ml at baseline. Thirty-nine (55.7%) patients in the TB group were diagnosed with extrapulmonary/disseminated TB. The median duration of concurrent administration of nevirapine and rifampin was 5.4 (4.6-6.1) months. By intention-to-treat analysis, the percentage of patients who achieved HIV-1 RNA <50 copies/ml was 52.9% in the TB group and 50% in control group (p = 0.866; odds ratio 1.121, 95% confidence interval 0.578-2.176); median (IQR) CD4 counts were 352 (271-580) cells/mm(3) and 425 (308-615) cells/mm(3) in the corresponding groups (p = 0.238). The proportion of ART discontinuation due to any reason at 1, 2, 3, and 4 years was 21%, 34%, 37%, and 46% in the TB group and 21%, 36%, 43%, and 49% in the control group, respectively (p = 0.651). The 4-year mortality rate was 6.4% in both groups. Conclusions: Nevirapine-based ART is an option for HIV-infected patients who receive rifampin in resource-limited countries or those who cannot tolerate efavirenz. (C) 2010 International Society for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.
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