期刊
INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH
卷 20, 期 5, 页码 479-486出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ijir.2008.33
关键词
prostatectomy; erectile dysfunction; sildenafil citrate
资金
- Pfizer Inc
Four weeks after bilateral nerve-sparing radical retropubic prostatectomy, men with normal erectile function before surgery were randomized to double-blind sildenafil (50 or 100mg) or placebo nightly for 36 weeks, followed by an 8-week drug-free period before assessment of erectile function. Enrollment was prematurely ceased and only 76 men completed because, assuming a placebo response rate similar to the published literature (for example, 34% in meta- analysis), the 25% response at blinded interim review suggested a lack of treatment effect. On the contrary, spontaneous erectile function (a combined score of >= 8 for questions 3 and 4 of the International Index of Erectile Function and a positive response to ` Were erections good enough for satisfactory sexual activity?') occurred in only 4% of the placebo group (n=1 of 25) versus 27% (n=14 of 51, P=0.0156, Fisher's exact test) of the sildenafil group. Nightly sildenafil administration for 36 weeks after surgery markedly increased the return of normal spontaneous erections.
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