期刊
INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY
卷 26, 期 3, 页码 585-596出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/039463201302600302
关键词
systemic lupus erythematosus; SLE pathogenesis; biologic therapies; belimumab; auto immune diseases; autoantibodies
Systemic lupus erythematosus (SLE) is the prototype of autoimmune diseases with multiorgan involvement. SLE presents many genetic and epigenetic associations and the pathogenesis is characterized by a complex network of alterations affecting both adaptative and innate immunity. The disclosure of novel mechanisms of SLE pathogenesis suggested new therapeutic targets, based on interference with the cytokine pathways or on depletion of the immune cells.
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