期刊
INTERNATIONAL JOURNAL OF HYPERTHERMIA
卷 26, 期 3, 页码 211-223出版社
TAYLOR & FRANCIS LTD
DOI: 10.3109/02656731003596259
关键词
tumour blood flow; tumour oxygenation; tumour pH; tumour bioenergetics; hyperthermia
资金
- Erwin Braun Foundation, Basel (Switzerland)
Changes in tumour oxygenation tend to reflect alterations in blood flow upon hyperthermia. An initial improvement in the oxygenation status, followed by a return to baseline levels (or even a drop to below baseline at high thermal doses) has been reported for some tumours, whereas a predictable and universal occurrence of sustained increases in O-2 tensions upon mild hyperthermia is questionable and still needs to be verified in the clinical setting. Clarification of the pathogenetic mechanisms behind possible sustained increases is mandatory. High-dose hyperthermia leads to a decrease in the extracellular and intracellular pH and a deterioration of the energy status, both of which are known to be parameters capable of acting as direct sensitisers and thus pivotal factors in hyperthermia treatment. The role of the tumour microcirculatory function, hypoxia, acidosis and energy status is complex and is further complicated by a pronounced heterogeneity. These latter aspects require additional critical evaluation in clinically relevant tumour models in order for their impact on the response to heat to be clarified.
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