期刊
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
卷 222, 期 2, 页码 168-176出版社
ELSEVIER GMBH
DOI: 10.1016/j.ijheh.2018.09.001
关键词
Long-term exposure; PM2.5; Ozone (O-3); Subclinical atherosclerosis; Women's health
资金
- National Institutes of Health (NIH), DHHS, through the National Institute on Aging (NIA)
- National Institute of Nursing Research (NINR)
- NIH Office of Research on Women's Health (ORWH) [U01NR004061, U01AG012505, U01AG012535, U01AG012531, U01AG012539, U01AG012546, U01AG012553, U01AG012554, U01AG012495, U01AG017719]
- National Center for Research Resources
- National Center for Advancing Translational Sciences, National Institutes of Health, through UCSF-CTSI [UL1 RR024131]
Introduction: Effects of more than one-year exposure to air pollution on atherosclerosis is seldom studied. This paper aims to examine the association between five-year exposure to particulate matter <= 2.5 mu m (PM2.5), ozone (O-3) and atherosclerosis observed about seven years later in late midlife women. Material and methods: This study was conducted among 1188 women of the Study of Women's Health Across the Nation (SWAN) from five sites, Detroit, MI; Oakland, CA; Pittsburgh, PA; Chicago, IL; and Newark, NJ, with available data on both air pollutant exposure and carotid ultrasound scans. Five-year mean annualized exposure levels of two air pollutants, PM2.5 and ozone (O-3), were collected during 5 SWAN visits (1999-2005) from monitors 20 km within the participant's residential address. Linear regression models were used to estimate the association of prior five-year mean annualized exposure to PM2.5 and O-3 with common carotid intima-media thickness (cIMT) and inter-adventitial diameter (IAD) examined approximately seven years later (2009-2013). Logistic and multinomial logistic regressions were applied to assess the associations of air pollutants with plaque presence and plaque index, respectively. Results: At time of carotid ultrasound scan, women were on average 59.6 (+/- 2.7) years old and a majority was postmenopausal (88.4%). The women were White (48.4%), Black (31.2%), Chinese (13.3%) and Hispanic (7.1%). A 1 mu g/m(3) higher 5-year mean annualized exposure to PM2.5 was associated with an 8.0 mu m(3) (95% CI: 1.0-15.1) greater maximum cIMT at a later mid-life, adjusting for cardiovascular disease risk factors; but was only related to IAD after adjusting for site. No association was found between either pollutant and plaque presence or plaque index. Conclusions: Long-term exposure to PM2.5 may contribute to elevated risk of atherosclerosis in the post-menopausal period.
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