期刊
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
卷 216, 期 6, 页码 755-762出版社
ELSEVIER GMBH, URBAN & FISCHER VERLAG
DOI: 10.1016/j.ijheh.2013.02.008
关键词
Plasma; Polychlorinated biphenyls; Dwellings; Indoor air; Questionnaire; GC-MS
资金
- Danish National Board of Health/Danish Ministry of Health
- Danish National Board of Health
Background: In the 1950s-1970s polychlorinated biphenyls (PCBs) were used in several countries as plasticizers in elastic sealants in buildings. Objective: The primary objective was to study whether residents of PCB-contaminated dwellings had higher plasma levels of PCBs than their neighbours in non-contaminated dwellings. The secondary objective was to study possible associations between concentrations of PCBs in the indoor air and in the plasma of residents. Methods: Stratified cross-sectional study of residents of a housing estate with four sections, of which only one section had PCB-containing sealants. The determination of 27 PCB congeners in plasma was performed among 134 exposed and 139 non-exposed residents. Air measurements were conducted in 104 flats. Results: Significant differences in plasma PCBs between exposed versus non-exposed were found for most of the lower chlorinated and many of the higher chlorinated congeners. The median of sum of 27 PCBs was approximately four times higher in exposed compared with non-exposed residents. The elevated PCB concentrations persisted in multivariable analyses controlling for relevant cofactors. We found significant correlations between PCB indoor air concentrations and the PCB concentration in the plasma of the residents for ten of the lower chlorinated congeners. Conclusion: Our study confirms that indoor air exposure to PCBs from PCB containing sealants may result in a considerable internal PCBs exposure of the residents. For the first time we were able to demonstrate that the internal exposure to low chlorinated PCBs is significantly associated with the indoor air concentration of these congeners. (C) 2013 Elsevier GmbH. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据