期刊
INTERNATIONAL JOURNAL OF HEMATOLOGY
卷 99, 期 5, 页码 531-541出版社
SPRINGER JAPAN KK
DOI: 10.1007/s12185-014-1552-8
关键词
Hematopoiesis; Long noncoding RNAs (lncRNAs); Leukemia
类别
资金
- Pathway to Independence Award from the National Institutes of Health, National Heart, Lung, and Blood Institute [1K99HL118157-01]
- National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases [DK068348]
- National Institutes of Health, National Heart, Lung, and Blood Institute [5P01 HL066105]
Long noncoding RNAs (lncRNAs) are increasingly recognized to contribute to cellular development via diverse mechanisms during both health and disease. Here, we highlight recent progress on the study of lncRNAs that function in the development of blood cells. We emphasize lncRNAs that regulate blood cell fates through epigenetic control of gene expression, an emerging theme among functional lncRNAs. Many of these noncoding genes and their targets become dysregulated during malignant hematopoiesis, directly implicating lncRNAs in blood cancers such as leukemia. In a few cases, dysregulation of an lncRNA alone leads to malignant hematopoiesis in a mouse model. Thus, lncRNAs may be not only useful as markers for the diagnosis and prognosis of cancers of the blood, but also as potential targets for novel therapies.
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