期刊
INTERNATIONAL JOURNAL OF HEMATOLOGY
卷 97, 期 3, 页码 397-402出版社
SPRINGER JAPAN KK
DOI: 10.1007/s12185-013-1282-3
关键词
Lymphoma; Large B-cell; Diffuse; Tumor burden
类别
资金
- national R&D Program for Cancer Control
- Ministry for Health, Welfare and Family Affairs, Republic of Korea [0920050]
- Korean Health Technology RD Project
- Ministry of Health and Welfare, Republic of Korea [A070001]
The objective of present study was to compare the prognosis of diffuse large B-cell lymphoma (DLBCL) with Waldeyer's ring involvement (WR-DLBCL) to that of nodal DLBCL (N-DLBCL) without WR involvement. Between July 2004 and October 2009, medical records and metabolic tumor volume (MTV) measured by 2-[fluorine-18]-fluoro-2-deoxy-d-glucose (F-18-FDG) positron emission tomography /computed tomography were collected from patients confirmed with DLBCL. All patients received six or eight cycles of R-CHOP therapy. One hundred and eight patients were included and categorized into WR-DLBCL and N-DLBCL groups. WR involvement and other prognostic factors were analyzed for survivals. High international prognostic index score and high MTV were independent poor prognostic factors. However, WR involvement was a good prognostic factor only in univariate analysis. This study suggests that tumor burden appeared to be more important than specific organ involvement for the prognosis of DLBCL.
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