期刊
INTERNATIONAL JOURNAL OF HEMATOLOGY
卷 95, 期 5, 页码 577-580出版社
SPRINGER TOKYO
DOI: 10.1007/s12185-012-1044-7
关键词
AML; Pediatric; Eosinophilia; t(16;21)(q24;q22); RUNX1-CBFA2T3
类别
资金
- Grants-in-Aid for Scientific Research [23591560, 23591537, 23591536, 24390268, 24591550, 22659196, 22591171] Funding Source: KAKEN
Acute myeloid leukemia with abnormal bone marrow eosinophilia (AML-M4Eo) is often reported in core binding factor (CBF) leukemia, with translocations such as inv(16)(p13q22), t(16;16)(p13;q22) or t(8;21)(q22;q22); however, it is rarely reported with t(16;21)(q24;q22), which produces the - (-) chimera. The similarity between this chimera and - (-) by t(8;21)(q22;q22) remains controversial. Adult leukemia with t(16;21)(q24;q22) was primarily therapy related, and shows poor prognosis; however, pediatric AML with this translocation was quite rare and tended to be de novo AML. We present here a 4-year-old boy with de novo AML-M4Eo and t(16;21)(q24;q22). He received chemotherapy and survived for more than 70 months without transplantation. We speculated that pediatric AML with t(16;21)(q24;q22) showed favorable prognosis, as with t(8;21)(q22;q22).
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