相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。Molecular Mechanism of beta-Arrestin-Biased Agonism at Seven-Transmembrane Receptors
Eric Reiter et al.
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 52 (2012)
Cytoprotective signaling by activated protein C requires protease-activated receptor-3 in podocytes
Thati Madhusudhan et al.
BLOOD (2012)
Thrombomodulin and its role in inflammation
Edward M. Conway
SEMINARS IN IMMUNOPATHOLOGY (2012)
Cytoprotective-Selective Activated Protein C Attenuates Pseudomonas aeruginosa-Induced Lung Injury in Mice
Nastasha Bir et al.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2011)
Purpura fulminans: recognition, diagnosis and management
E. Chalmers et al.
ARCHIVES OF DISEASE IN CHILDHOOD (2011)
Factor VIIa bound to endothelial cell protein C receptor activates protease activated receptor-1 and mediates cell signaling and barrier protection
Prosenjit Sen et al.
BLOOD (2011)
Structural insights into agonist-induced activation of G-protein-coupled receptors
Xavier Deupi et al.
CURRENT OPINION IN STRUCTURAL BIOLOGY (2011)
Multiple receptor-mediated functions of activated protein C
H. Weiler
HAMOSTASEOLOGIE (2011)
Activated Protein C N-Linked Glycans Modulate Cytoprotective Signaling Function on Endothelial Cells
Fionnuala Ni Ainle et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
The Endothelial Protein C Receptor Supports Tissue Factor Ternary Coagulation Initiation Complex Signaling through Protease-activated Receptors
Jennifer Disse et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Activated Protein C Enhances Human Keratinocyte Barrier Integrity via Sequential Activation of Epidermal Growth Factor Receptor and Tie2
Meilang Xue et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Thrombomodulin: protectorate God of the vasculature in thrombosis and inflammation
T. Ito et al.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2011)
Activated protein C promotes protease-activated receptor-1 cytoprotective signaling through β-arrestin and dishevelled-2 scaffolds
Unice J. K. Soh et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
The structure-function relationship of activated protein C Lessons from natural and engineered mutations
Karin C. A. A. Wildhagen et al.
THROMBOSIS AND HAEMOSTASIS (2011)
Cytoprotective protein C pathways and implications for stroke and neurological disorders
Berislav V. Zlokovic et al.
TRENDS IN NEUROSCIENCES (2011)
The protein C pathway in tissue inflammation and injury: pathogenic role and therapeutic implications
Silvio Danese et al.
BLOOD (2010)
Activated protein C cofactor function of protein S: a critical role for Asp95 in the EGF1-like domain
Helena M. Andersson et al.
BLOOD (2010)
Role of GTPases in control of microvascular permeability
Volker Spindler et al.
CARDIOVASCULAR RESEARCH (2010)
Regulation of the Protein C Anticoagulant and Antiinflammatory Pathways
A. R. Rezaie
CURRENT MEDICINAL CHEMISTRY (2010)
Activated protein C utilizes the angiopoietin/Tie2 axis to promote endothelial barrier function
Nikita Minhas et al.
FASEB JOURNAL (2010)
The association of protein S Tokushima-K196E with a risk of deep vein thrombosis
Makoto Ikejiri et al.
INTERNATIONAL JOURNAL OF HEMATOLOGY (2010)
Reevaluation of the role of HDL in the anticoagulant activated protein C system in humans
Cecilia Oslakovic et al.
JOURNAL OF CLINICAL INVESTIGATION (2010)
Activated protein C targets CD8+ dendritic cells to reduce the mortality of endotoxemia in mice
Edward Kerschen et al.
JOURNAL OF CLINICAL INVESTIGATION (2010)
The efficacy of activated protein C in murine endotoxemia is dependent on integrin CD11b
Chunzhang Cao et al.
JOURNAL OF CLINICAL INVESTIGATION (2010)
APC resistance: biological basis and acquired influences
E. Castoldi et al.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2010)
Zn2+-containing protein S inhibits extrinsic factor X-activating complex independently of tissue factor pathway inhibitor
N. Fernandes et al.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2010)
Coagulation factor Xa cleaves protease-activated receptor-1 and mediates signaling dependent on binding to the endothelial protein C receptor
R. A. Schuepbach et al.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2010)
Factor V Is an Anticoagulant Cofactor for Activated Protein C during Inactivation of Factor Va
Thomas J. Cramer et al.
pathophysiology of haemostasis and thrombosis (2010)
The role of activated protein C in cancer progression
Geerte L. van Sluis et al.
THROMBOSIS RESEARCH (2010)
Factor VIIa interaction with endothelial cells and endothelial cell protein C receptor
Usha R. Pendurthi et al.
THROMBOSIS RESEARCH (2010)
Protein S as Cofactor for TFPI
Tilman M. Hackeng et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2009)
Recombinant human activated protein C inhibits integrin-mediated neutrophil migration
Gwendolyn F. Elphick et al.
BLOOD (2009)
Hyperantithrombotic, noncytoprotective Glu149Ala-activated protein C mutant
Laurent O. Mosnier et al.
BLOOD (2009)
Activated Protein C and Acute Kidney Injury: Selective Targeting of PAR-1
Akanksha Gupta et al.
CURRENT DRUG TARGETS (2009)
Neuroprotective activities of activated protein C mutant with reduced anticoagulant activity
Huang Guo et al.
EUROPEAN JOURNAL OF NEUROSCIENCE (2009)
Plasma protein S contains zinc essential for efficient activated protein C-independent anticoagulant activity and binding to factor Xa, but not for efficient binding to tissue factor pathway inhibitor
Mary J. Heeb et al.
FASEB JOURNAL (2009)
Role of Rac 1 and cAMP in Endothelial Barrier Stabilization and Thrombin-induced Barrier Breakdown
Y. Baumer et al.
JOURNAL OF CELLULAR PHYSIOLOGY (2009)
Species-dependent neuroprotection by activated protein C mutants with reduced anticoagulant activity
Huang Guo et al.
JOURNAL OF NEUROCHEMISTRY (2009)
Regulation of TFPI function by protein S
T. M. Hackeng et al.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2009)
Modulation of sepsis outcome with variants of activated protein C
H. Weiler et al.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2009)
Regulation of vascular permeability by sphingosine 1-phosphate
Lichun Wang et al.
MICROVASCULAR RESEARCH (2009)
Proteases Display Biased Agonism at Protease-Activated Receptors: Location Matters!
Angela Russo et al.
MOLECULAR INTERVENTIONS (2009)
Extracellular histones are major mediators of death in sepsis
Jun Xu et al.
NATURE MEDICINE (2009)
Thrombomodulin Mutations in Atypical Hemolytic-Uremic Syndrome
Mieke Delvaeye et al.
NEW ENGLAND JOURNAL OF MEDICINE (2009)
Activated protein C ligation of ApoER2 (LRP8) causes Dab1-dependent signaling in U937 cells
Xia V. Yang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Caveolae are required for protease-selective signaling by protease-activated receptor-1
Angela Russo et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Wnt5A/CaMKII signaling contributes to the inflammatory response of macrophages and is a target for the antiinflammatory action of activated protein C and interleukin-10
Claudia Pereira et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2008)
Advances in understanding pathogenic mechanisms of thrombophilic disorders
Bjorn Dahlback
BLOOD (2008)
Alternative mRNA is favored by the A3 haplotype of the EPCR gene PROCR and generates a novel soluble form of EPCR in plasma
Beatrice Saposnik et al.
BLOOD (2008)
New therapeutic applications for the anticoagulant, activated protein C
Chris Jackson et al.
EXPERT OPINION ON BIOLOGICAL THERAPY (2008)
CoagMDB: A database analysis of missense mutations within four conserved domains in five vitamin K-dependent coagulation serine proteases using a text-mining tool
Rebecca E. Saunders et al.
HUMAN MUTATION (2008)
Activated protein C-An anticoagulant that does more than stop clots
Christopher J. Jackson et al.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2008)
Dissociation of Activated Protein C Functions by Elimination of Protein S Cofactor Enhancement
Shona Harmon et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Detailed mechanisms of the inactivation of factor VIIIa by activated protein C in the presence of its cofactors, protein S and factor V
Andrew J. Gale et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Protein C supports platelet binding and activation under flow: role of glycoprotein Ib and apolipoprotein E receptor 2
T. C. White et al.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2008)
Lipid raft localization regulates the cleavage specificity of protease activated receptor 1 in endothelial cells
J. -S. Bae et al.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2008)
Proteomic analysis of active multiple sclerosis lesions reveals therapeutic targets
May H. Han et al.
NATURE (2008)
Activated protein C-cleaved protease activated receptor-1 is retained on the endothelial cell surface even in the presence of thrombin
Reto A. Schuepbach et al.
BLOOD (2008)
The ligand occupancy of endothelial protein C receptor switches the protease-activated receptor 1-dependent signaling specificity of thrombin from a permeability-enhancing to a banier-protective response in endothelial cells
Jong-Sup Bae et al.
BLOOD (2007)
Activated protein C mutant with minimal anticoagulant activity, normal cytoprotective activity, and preservation of thrombin activable fibrinolysis inhibitor-dependent cytoprotective functions
Laurent O. Mosnier et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Activated protein C protects against diabetic nephropathy by inhibiting endothelial and podocyte apoptosis
Berend Isermann et al.
NATURE MEDICINE (2007)
Endotoxemia and sepsis mortality reduction by non-anticoagulant-activated protein C
Edward J. Kerschen et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2007)
Identification of a specific exosite on activated protein C for interaction with protease-activated receptor 1
Likui Yang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Protease-activated receptor signaling: new roles and regulatory mechanisms
Stephen F. Traynelis et al.
CURRENT OPINION IN HEMATOLOGY (2007)
Identification and computationally-based structural interpretation of naturally occurring variants of human protein C
Ermanna Rovida et al.
HUMAN MUTATION (2007)
High-density lipoprotein and the risk of recurrent venous thromboembolism
Sabine Eichinger et al.
CIRCULATION (2007)
Engineering a disulfide bond to stabilize the calcium-binding loop of activated protein C eliminates its anticoagulant but not its protective signaling properties
Jong-Sup Bae et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Receptors of the protein C activation and activated protein C signaling pathways are colocalized in lipid rafts of endothelial cells
Jong-Sup Bae et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Regulated endothelial protein C receptor shedding is mediated by tumor necrosis factor-α converting enzyme/ADAM17
D. Qu et al.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2007)
ProCMD: a database and 3D web resource for protein C mutants
Pasqualina D'Ursi et al.
BMC BIOINFORMATICS (2007)
Polymorphisms in vitamin K-dependent γ-carboxylation-related genes influence interindividual variability in plasma protein C and protein S activities in the general population
Rina Kimura et al.
INTERNATIONAL JOURNAL OF HEMATOLOGY (2006)
Activated protein C inhibits tissue plasminogen activator-induced brain hemorrhage
Tong Cheng et al.
NATURE MEDICINE (2006)
Protease-activated receptors in cardiovascular diseases
Andrew J. Leger et al.
CIRCULATION (2006)
Endothelial and antithrombotic actions of HDL
Chieko Mineo et al.
CIRCULATION RESEARCH (2006)
Intrinsic stability and functional properties of disulfide bond-stabilized coagulation factor VIIIa variants
A. J. . Gale et al.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2006)
Genetic risk factors for deep vein thrombosis among Japanese: Importance of protein SK196E mutation
T Miyata et al.
INTERNATIONAL JOURNAL OF HEMATOLOGY (2006)
Inflammation and the activated protein C anticoagulant pathway
Charles T. Esmon
SEMINARS IN THROMBOSIS AND HEMOSTASIS (2006)
Protein S stimulates inhibition of the tissue factor pathway by tissue factor pathway inhibitor
TM Hackeng et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
The SWISS-MODEL workspace: a web-based environment for protein structure homology modelling
K Arnold et al.
BIOINFORMATICS (2006)
Proteolytic cleavage of protein S during the hemostatic response
HJM Brinkman et al.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2005)
New concepts in drug discovery: Collateral efficacy and permissive antagonism
T Kenakin
NATURE REVIEWS DRUG DISCOVERY (2005)
Functional recovery after embolic stroke in rodents by activated protein C
BV Zlokovic et al.
ANNALS OF NEUROLOGY (2005)
High-density lipoprotein deficiency and dyslipoproteinemia associated with venous thrombosis in men
H Deguchi et al.
CIRCULATION (2005)
Solution structure of the Ca2+-binding EGF3-4 pair from vitamin K-Dependent protein S:: Identification of an unusual fold in EGF3
T Drakenberg et al.
BIOCHEMISTRY (2005)
Activated protein C mediates novel lung endothelial barrier enhancement - Role of sphingosine 1-phosphate receptor transactivation
JH Finigan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Endothelial barrier protection by activated protein C through PAR1-dependent sphingosine 1-phosphate receptor-1 crossactivation
C Feistritzer et al.
BLOOD (2005)
Selective modulation of protein C affinity for EPCR and phospholipids by Gla domain mutation
RJS Preston et al.
FEBS JOURNAL (2005)
Factor V Leiden: a disorder of factor V anticoagulant function
E Castoldi et al.
CURRENT OPINION IN HEMATOLOGY (2004)
Sphingolipids as bioactive regulators of thrombin generation
H Deguchi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Activated protein C prevents neuronal apoptosis via protease activated receptors 1 and 3
H Guo et al.
NEURON (2004)
Coagulation, inflammation, and apoptosis: different roles for protein S and the protein S-C4b binding protein complex
SM Rezende et al.
BLOOD (2004)
Characterization of a thrombomodulin binding site on protein C and its comparison to an activated protein C binding site for factor Va
AJ Gale et al.
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS (2004)
The discovery of thrombomodulin
CT Esmon et al.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2004)
Direct anticoagulant activity of protein S-C4b binding protein complex in Heerlen heterozygotes and normals
MJ Heeb et al.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2004)
Activated protein C variants with normal cytoprotective but reduced anticoagulant activity
LO Mosnier et al.
BLOOD (2004)
Thrombomodulin-protein C-EPCR system - Integrated to regulate coagulation and inflammation
M Van de Wouwer et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2004)
Tissue plasminogen activator neurovascular toxicity is controlled by activated protein C
D Liu et al.
NATURE MEDICINE (2004)
Expression and function of the endothelial protein C receptor in human neutrophils
DH Sturn et al.
BLOOD (2003)
Inhibition of staurosporine-induced apoptosis of endothelial cells by activated protein C requires protease-activated receptor-1 and endothelial cell protein C receptor
LO Mosnier et al.
BIOCHEMICAL JOURNAL (2003)
Activated protein C alters cytosolic calcium flux in human brain endothelium via binding to endothelial protein C receptor and activation of protease activated receptor-1
E Dömötör et al.
BLOOD (2003)
Recombinant murine-activated protein C is neuroprotective in a murine ischemic stroke model
JA Fernández et al.
BLOOD CELLS MOLECULES AND DISEASES (2003)
Glucosylceramide, a neutral glycosphingolipid anticoagulant cofactor, enhances the interaction of human- and bovine-activated protein C with negatively charged phospholipid vesicles
S Yegneswaran et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Science review: Role of coagulation protease cascades in sepsis
M Riewald et al.
CRITICAL CARE (2003)
Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective
T Cheng et al.
NATURE MEDICINE (2003)
Exosite-dependent regulation of the protein C anticoagulant pathway
AR Rezaie
TRENDS IN CARDIOVASCULAR MEDICINE (2003)
Molecular characterization of an extended binding site for coagulation factor Va in the positive exosite of activated protein C
AJ Gale et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Activation of endothelial cell protease activated receptor 1 by the protein C pathway
M Riewald et al.
SCIENCE (2002)
Factor v and thrombotic disease -: Description of a janus-faced protein
GAF Nicolaes et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2002)
Neutral glycosphingolipid-dependent inactivation of coagulation factor Va by activated protein C and protein S
H Deguchi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Secondary substrate-binding exosite in the serine protease domain of activated protein C important for cleavage at Arg-506 but not at Arg-306 in factor Va
U Friedrich et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Gene expression profile of antithrombotic protein C defines new mechanisms modulating inflammation and apoptosis
DE Joyce et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Anti-inflammatory, antithrombotic, and neuroprotective effects of activated protein C in a murine model of focal ischemic stroke
M Shibata et al.
CIRCULATION (2001)
Plasma glucosylceramide deficiency as potential risk factor for venous thrombosis and modulator of anticoagulant protein C pathway
H Deguchi et al.
BLOOD (2001)
Thrombin signalling and protease-activated receptors
SR Coughlin
NATURE (2000)
PAR3 is a cofactor for PAR4 activation by thrombin
M Nakanishi-Matsui et al.
NATURE (2000)
Cardiolipin enhances protein C pathway anticoagulant activity
JA Fernández et al.
BLOOD CELLS MOLECULES AND DISEASES (2000)
分享论文
