期刊
INTERNATIONAL JOURNAL OF HEMATOLOGY
卷 95, 期 5, 页码 509-515出版社
SPRINGER TOKYO
DOI: 10.1007/s12185-012-1033-x
关键词
Acute myeloid leukemia; RAS; Late relapse; Prognosis; FAB
类别
资金
- Ministry of Health, Labour, and Welfare of Japan
- Ministry of Education, Culture, Sports, Science, and Technology of Japan
- Grants-in-Aid for Scientific Research [23591537, 22591171, 21390316, 22659196, 23591560, 22591172, 24390268] Funding Source: KAKEN
Mutations in are frequent in acute myeloid leukemia (AML), and are thought to contribute to leukemogenesis in a subset of patients; however, their prognostic significance has not been firmly established. One hundred and fifty-seven pediatric patients with AML were analyzed for and mutations around hot spots at codons 12, 13, and 61. Twenty-nine patients (18.5%) had an activating mutation of . We found mutations to be more frequent than mutations (18/29, 62.1% of patients with mutation), in contrast to previous reports (18-40%). The frequency of mutation was higher in French-American-British types M4 and M5 than other types ( = 0.02). There were no significant differences in other clinical manifestations or distribution in cytogenetic subgroups, or aberrations of other genes, including mutation, -ITD, and -PTD, between patients with and without mutations. No significant differences were observed in the 3-year overall survival and disease-free survival; however, the presence of mutation was related to late relapse. The occurrence of clinical events at relatively late period should be monitored for in AML patients with mutations in .
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