期刊
INTERNATIONAL JOURNAL OF HEMATOLOGY
卷 96, 期 2, 页码 274-278出版社
SPRINGER JAPAN KK
DOI: 10.1007/s12185-012-1118-6
关键词
Progressive multifocal leukoencephalopathy; Mantle cell lymphoma; Rituximab; Bendamustine
类别
A 66-year-old female developed progressive multifocal leukoencephalopathy (PML) 17 months after treatment with bendamustine and rituximab chemoimmunotherapy. During her evaluation for PML, she was found to have a CD4 count of 176 cells/mu L (reference range 492-1740). The patient demonstrated spontaneous recovery of symptoms that occurred in parallel with recovery of the CD4 counts. While PML is associated with rituximab therapy, the timing and patients' clinical course are atypical, raising the possibility of a previously unreported association with bendamustine therapy.
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