期刊
INTERNATIONAL JOURNAL OF HEMATOLOGY
卷 94, 期 2, 页码 134-141出版社
SPRINGER TOKYO
DOI: 10.1007/s12185-011-0905-9
关键词
Leukemia; Transcription factor; Transcriptional coactivator
类别
Specific chromosomal translocations and other mutations associated with acute myeloblastic leukemia (AML) often involve transcription factors and transcriptional coactivators. Such target genes include AML1, C/EBP alpha, RAR alpha, MOZ, p300/CBP, and MLL, all of which are important in the regulation of hematopoiesis. The resultant fusion or mutant proteins deregulate the transcription of the affected genes and disrupt their essential role in hematopoiesis, causing differentiation block and abnormal proliferation and/or survival. This review focuses on such transcription factors and coactivators, and describes their roles in leukemogenesis and hematopoiesis.
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