期刊
INTERNATIONAL JOURNAL OF HEMATOLOGY
卷 91, 期 2, 页码 229-237出版社
SPRINGER JAPAN KK
DOI: 10.1007/s12185-010-0495-y
关键词
Heme oxygenase; Hemophagocytic syndrome; Ferritin; Macrophage
类别
资金
- Ministry of Health, Labor, and Welfare of Japan
- Ministry of Education, Culture, Sports, and Technology of Japan [20591174]
- Yokohama Foundation for Advancement of Medical Science
- Grants-in-Aid for Scientific Research [20591174] Funding Source: KAKEN
Heme oxygenase (HO)-1, a heme-degrading enzyme inducible by various stimuli, plays a key role in the regulation of inflammatory response in monocytes/macrophages. The serum HO-1 level is remarkably increased in patients with secondary hemophagocytic syndrome (HPS) or adult-onset Still's disease. We measured serum HO-1 levels in patients with a variety of hematological diseases, including secondary HPS, by means of ELISA. Serum HO-1 levels were significantly higher in 22 patients with HPS (134.7 +/- 116.2 ng/mL, P < 0.0001) at diagnosis than in 80 patients with other hematological diseases. The most effective cutoff point between HPS and other conditions was 14.5 ng/mL, with 100.0% sensitivity and 96.3% specificity. In HPS patients, the serum HO-1 levels showed the highest correlation with serum ferritin (r = 0.682, P = 0.0005), which reflects the disease activity of HPS. Moreover, both HO-1 and ferritin levels were reduced in parallel after successful treatment in patients with HPS, irrespective of underlying diseases. However, HO-1 levels were not elevated in patients with other causes of hyperferritinemia. These data demonstrate that serum HO-1 can distinguish secondary HPS from other hematological diseases, including those associated with hyperferritinemia.
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