期刊
INTERNATIONAL JOURNAL OF HEMATOLOGY
卷 92, 期 1, 页码 136-143出版社
SPRINGER JAPAN KK
DOI: 10.1007/s12185-010-0627-4
关键词
Ellagic acid; Acute myeloid leukemia cells; Apoptosis; Caspase; Differentiation; ATRA
类别
资金
- Japan Society for the Promotion of Science [18591091]
- Ministry of Health, Labor and Welfare of Japan
- Grants-in-Aid for Scientific Research [18591091] Funding Source: KAKEN
All-trans retinoic acid (ATRA) is a standard drug used for differentiation therapy in acute promyelocytic leukemia. To potentiate this therapy, we examined the effect of ellagic acid (EA), a natural polyphenolic compound with antiproliferative and antioxidant properties, on the growth and differentiation of HL-60 acute myeloid leukemia cells. EA was found to induce apoptosis, which was blocked by pan-caspase inhibitor, Z-VAD-FMK. EA activated the caspase-3 pathway and enhanced the expressions of myeloid differentiation markers (CD11b, MRP-14 protein, granulocytic morphology) induced by ATRA treatment. These results indicate that EA is a potent apoptosis inducer and also effectively potentiates ATRA-induced myeloid differentiation of HL-60 cells.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据