期刊
INTERNATIONAL JOURNAL OF HEMATOLOGY
卷 91, 期 5, 页码 808-819出版社
SPRINGER JAPAN KK
DOI: 10.1007/s12185-010-0567-z
关键词
BAFF; B cell precursor ALL; Burkitt lymphoma; Apoptosis
类别
资金
- Japan Health Sciences Foundation for Research on Publicly Essential Drugs and Medical Devices [KHA1004]
- Health and Labour Sciences Research Grants [H19-010]
- Ministry of Health, Labour and Welfare of Japan
B cell-activating factor belonging to the tumor necrosis factor superfamily (BAFF) is a crucial factor for B cell development and is involved in the survival of malignant B cells, but its effect on B cell precursors (BCPs) remains unclear. We investigated BCP acute lymphoblastic leukemia (-ALL) cells for BAFF receptor (-R) expression and compared the effect of BAFF on BCP-ALL cells and Burkitt lymphoma (BL) cells. Expression of BAFF-R was detected in some cell lines and some clinical specimens of both BL and BCP-ALL. BAFF acted on both BL and BCP-ALL cells and promoted proliferation by both. BAFF also inhibited apoptosis by BL cells induced by cross-linking of cell surface molecules and anticancer drugs, but failed to inhibit apoptosis by BCP-ALL cells. BAFF induced prompt and obvious activation of the NF-kappa B signaling pathway in BL cells, but only weak and delayed activation of the pathway in BCP-ALL cells. The results of this study indicate that some BCP-ALL cells and some BL cells express BAFF-R, but that the effects of BAFF on BCP-ALL cells are different from its effects on mature B cell malignancies.
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