期刊
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
卷 143, 期 2, 页码 217-224出版社
WILEY
DOI: 10.1002/ijgo.12628
关键词
Cohort; Cytology; Female sex workers; High-risk women; HPV screening; Kenya; Self-collection
资金
- Hologic/Gen-Probe Incorporated
- Center for AIDS Research, University of North Carolina at Chapel Hill
Objective: To compare accuracy of detecting high-grade cervical lesions (squamous intraepithelial lesions or greater, HSIL+) by high-risk HPV messenger RNA (hrHPV-RNA) testing between physician- and self-collected specimens, and by conventional cytology. Methods: The present prospective longitudinal study included data collected among female sex workers (FSWs) in Nairobi, Kenya, between December 2, 2009, and February 15, 2013. Participants self-collected cervico-vaginal specimens for hrHPV-RNA testing, and a physician collected cervical specimens for hrHPV-RNA testing and conventional cytology. hrHPV-RNA testing was conducted every 3months, and conventional cytology every 6months. Results: Overall, 350 FSWs aged 18-50years participated. hrHPV-RNA prevalence decreased slightly from 29.9% (103/344) at baseline to 24.3% (53/218) at 24months for physician-collected, and 28.5% (98/344) to 24.3% (53/218) for self-collected specimens. Agreement between the sampling methods appeared to increase over time (baseline 0.55, 95% confidence interval [CI] 0.45-0.65; 24months 0.83, 95% CI 0.74-0.91). Among 21 patients with HSIL+ over 24months, 18 (86%) and 17 (81%) had hrHPV-RNA-positive results at baseline in physician- and self-collected specimens, respectively; and 20 (95%) had baseline hrHPV-RNA-positive results or cytology anomalies. Conclusion: Overall agreement between physician- and self-collected hrHPV-RNA results was moderate and appeared to increase over time. Baseline physician- and self-collected hrHPV-RNA tests were similarly strong indicators of cumulative HSIL+ over 24months.
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