期刊
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
卷 105, 期 1, 页码 46-49出版社
WILEY
DOI: 10.1016/j.ijgo.2008.12.001
关键词
Cortisol; Estradiol; Maternal hormones; Pregnancy trimester; Progesterone; Psychologic distress
资金
- Foundation of Van Science and Technique Plan of China [GG04137]
Objective: To investigate links between psychologic distress and levels of maternal hormones and cortisol during pregnancy and Post partum. Method: The study population of 308 pregnant or recently delivered women was divided into 4 equal groups, 3 representing each pregnancy trimester and the fourth one representing the first week of the postpartum period. The women were screened for psychological distress and had blood drawn to measure serum levels of estradiol, progesterone, and total cortisol on the same day. Results: The rates of anxiety and depression were higher in the first trimester and the postpartum groups. Depression was correlated with sharp changes in estradiol and progesterone levels: anxiety was correlated with total cortisol level: and there was a correlation between depression and anxiety. Conclusion: Sharp changes in maternal hormone levels were correlated with depression; depression was correlated with anxiety; and anxiety was correlated with elevated cortisol levels, which may adversely affect the health of mother and offspring. Measuring maternal hormones may be a diagnostic tool to evaluate psychologic stress and associated risks. (C) 2008 Published by Elsevier Ireland Ltd. on behalf of International Federation of Gynecology and Obstetrics.
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