期刊
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
卷 108, 期 2, 页码 148-151出版社
WILEY
DOI: 10.1016/j.ijgo.2009.09.021
关键词
Hirsutism; Hyperandrogenemia; Polycystic ovary syndrome; Obesity; Type 2 diabetes
资金
- Science Technology Research Project of Guangdong Province [2008B080701026, 2007B080701014]
- Mega-projects of Science Research for the 11th Five-Year Plan of China [2007BA104B00]
- Medical Science Research Foundation of Guangdong Province [B2007053]
- Ministry of Education of China [20050558093]
Objective: To evaluate the effect of hyperandrogenism on metabolic disorders among patients with polycystic ovary syndrome (PCOS) diagnosed using the Rotterdam criteria. Methods: A retrospective analysis of the clinical records of 883 women with KOS and 717 premenopausal controls identified from the general population. Results: A total of 686 (77.7%) patients were classified with PCOS based on National Institutes of Health (NIH) criteria, and 164 out of 197 (83.2%) additional patients had no hyperandrogenism. Women with normal androgen levels exhibited lower frequencies of obesity, type 2 diabetes, acanthosis nigricans, genetic history of diabetes, and elevated Matsuda index compared with hyperandrogenic patients. Hyperandrogenemia, but not hirsutism, was independently associated with the risk for type 2 diabetes (odds ratio [OR] 5.7; P=0.028) and obesity (OR 1.7; P = 0.005) among Chinese patients with PCOS. Conclusions: Hyperandrogenemia is associated with type 2 diabetes and obesity in Chinese women with PCOS and should be considered at first-line management of hyperandrogenism and infertility due to PCOS. (C) 2009 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.
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