期刊
MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS
卷 79, 期 2, 页码 225-241出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/MMBR.00061-14
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资金
- Danish Medical Research Council [12-124330]
- Novo Nordisk Foundation
- Lundbeck Foundation [R34-3855]
- Kathrine og Vigo Skovgaards Fond
- Aarhus University Research Foundation
- Fonden til Laegevidenskabens Fremme
The innate immune system provides early defense against infections and also plays a key role in monitoring alterations of homeostasis in the body. DNA is highly immunostimulatory, and recent advances in this field have led to the identification of the innate immune sensors responsible for the recognition of DNA as well as the downstream pathways that are activated. Moreover, information on how cells regulate DNA-driven immune responses to avoid excessive inflammation is now emerging. Finally, several reports have demonstrated how defects in DNA sensing, signaling, and regulation are associated with susceptibility to infections or inflammatory diseases in humans and model organisms. In this review, the current literature on DNA-stimulated innate immune activation is discussed, and important new questions facing this field are proposed.
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