期刊
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
卷 103, 期 1, 页码 55-58出版社
WILEY
DOI: 10.1016/j.ijgo.2008.05.031
关键词
Genotype; Collagen type 3 alpha 1 polymorphism; Pelvic organ prolapses
资金
- National Science Council of the Republic of China
- China Medical University
- China Medical University Hospital [NSC 96-2815-C-039-035-B, CMU96-035, DMR-97-076]
Objective: To investigate whether pelvic organ prolapse (POP) is associated with collogen 3 alpha 1 (COL3A1) polymorphisms and other factors. Methods: A case-control association study was conducted with 84 women affected with POP and 147 controls. The genotypes of nucleotides COL3A1 rs1800255 and COL3A1 rs1801184 polymorphisms were ascertained by polymerase chain reaction and restriction fragment length polymorphism analysis. Results: The distribution of the COL3A1 rs1800255 genotypes was significantly different among affected women and controls. Older age and incidence of COL3A1 rs1800255 genotype AA were significantly associated with risk of POP. Conclusion: There may be an association between COL3A1 genotype and risk of POP. (c) 2008 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.
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