Quality of Life and Sexual, Bladder, and Intestinal Dysfunctions After Class III Nerve-Sparing and Class II Radical Hysterectomies A Questionnaire-Based Study

Background: To compare quality of life and bladder, intestinal, and Sexual dysfunctions in 2 groups Of patients undergoing different types of radical hysterectomies (RHs). Methods: Patients with cervical cancer Who underwent RH have been enrolled in a questionnaire-based Study. Quality of life (QoL) and bladder, intestinal, and Sexual dysfunctions were evaluated with the Functional Assessment of Cancer Therapy-Cervix (FACT-Cx). Patients were grouped according to the type of RH: group I, class II RH and group 2, class III nerve-sparing RH (NSRH). Results: Of 157 women included in the Study, 127 filled Out file questionnaire. Overall, QoL score assessed with the FACT questionnaire did not differ significantly between the 2 groups. The FACT subscales assessing physical, functional, emotional, and social wellbeing did not differ significantly between the 2 groups, whereas the FACT-Cx subscales assessing disease-related symptoms in group 2 patients showed a significantly worse score (72 vs 66; P = 0.03). Evaluating Singularly the 15 items of the Cx subscales assessing disease-related symptoms, we did not find any significant difference between the 2 groups, but Only Cx1 (I am bothered by discharge or bleeding from my vagina) was significantly worse in group 2 patients. At univariate analysis, we found that NSRH and adjuvant radiotherapy (RT) impact negatively oil the FACT-Cx subscales regarding pelvic visceral function. However, at multivariate analysis, only adjuvant RT impact negatively. Conclusions: Patients Submitted to class III NSRH did not present worse QoL and pelvic visceral dysfunctions when compared with class II RH. The RT seems to be a factor impacting negatively oil bladder and sexual function.